THE PAGANO LABORATORY
The major goal of our laboratory is to discover the details of how timed degradation of regulatory proteins by the ubiquitin system controls cellular pathways that are fundamental to the mammalian cell division cycle. We also integrate insights from basic research with the study of human cancers. We believe that well-understood molecular mechanisms can inform about disease mechanisms and, consequently, vulnerabilities, true drug targets, combination therapies, and drug resistance.
UNDERSTANDING THE KEY DIMENSIONS OF CELLULAR LIFE
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